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Targeting macrophages as effectors of cancer immunotherapy


Term:

IAP

Department:

WI: Whitehead Institute For Biomedical Research

Faculty Supervisor:

Robert A. Weinberg, Ph.D.

Faculty email:

weinberg@wi.mit.edu

Apply by:

January 1, 2020

Contact:

Kipp Weiskopf, M.D., Ph.D. Contact Email: kipp@wi.mit.edu

Project Description

This UROP experience is for a project in the Weiskopf laboratory at the Whitehead Institute. The Weiskopf lab studies immune cells called macrophages. They are often the most common immune cells present in tumors, yet their ability to attack cancer has been underappreciated. We have found that macrophages can be manipulated to attack cancer cells when provided with an appropriate stimulus. The UROP project will focus on identifying new ways to stimulate macrophages to attack and eliminate cancer cells. The project will involve in vitro experiments in which human macrophages are combined with cancer cells to evaluate immune activation. There will also be opportunities to perform in vivo experiments using mouse models of cancer. The UROP student will have the opportunity to contribute to research publications resulting from this work. This UROP project will ideally be continued long-term with the expectation of full-time work during IAP and Summer 2020. Students with an interest in pursuing M.D., Ph.D., or M.D./Ph.D. programs are strongly encouraged to apply.

Pre-requisites

None.