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Research-Scale Automated Platform for Optimization of Photochemical Reactions adsa




10: Chemical Engineering

Faculty Supervisor:

Klavs F. Jensen

Faculty email:


Apply by:



Kakasaheb Nandiwale: kakayn@mit.edu

Project Description

Small volume continuous manufacturing is a key platform in pharmaceutical industry due to its small footprint, expanded processing space, and demonstrated benefits from the safety and product quality viewpoints. However, handling solids in flow is still a challenge. At research-scale flow reactors often clog due to solids formation when screening a wide range of conditions. The overall goal of the project is to design and develop state-of-the-art automated platform able to handle slurries/solids formed during a chemical transformation to achieve a robust reaction optimization. The proposed platform is based on a mini CSTR (Continuous-Stirred-Tank-Reactor) cascade approach. The constructed platform will be tested using organic/photochemical reactions involving solids/slurries. During this project, UROP students will have an opportunity to learn about automated optimization system, online analysis, and integration of software and hardware.


Student with some programming (MATLAB, Python, LabVIEW) and organic chemistry knowledge are welcome to apply.