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Precision control of CRISPR-associated enzymes


Term:

Spring

Department:

BI: Broad Institute

Faculty Supervisor:

Eric Lander

Faculty email:

lander@broadinstitute.org

Apply by:

2/10/20

Contact:

Amit Choudhary: achoud@broadinstitute.org

Project Description

Precision control lies at the heart of any powerful technology. The CRISPR (clustered regularly interspaced short palindromic repeat) system is a microbial adaptive immune system that has furnished transformative biomedical technologies for targeted genome and epigenome editing, sequence-specific DNA recognition, targeted gene expression or repression, and genome imaging. The rapid ascension of CRISPR-based genome editing technologies (e.g., gene drives) has raised biosafety concerns. Further, much interest exists to diversify these enzymes. You will join the Choudhary Lab to help develop methods to control and diversify CRISPR-Cas9/Cpf1 enzymes for genome engineering applications. You will work closely with a small team of postdoctoral fellows in chemistry and biology and have the opportunity to learn fundamental techniques and principles employed in organic chemistry, molecular and cell biology.

Pre-requisites

Some experience in organic chemistry, or cell and molecular biology desired, but not required.