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Measuring the genome of viruses for gene therapy: simulations & experiments




2: Mechanical Engineering

Faculty Supervisor:

Scott Manalis

Faculty email:


Apply by:

June 1st 2020


Yorgos Katsikis: geokats@mit.edu

Project Description

The long-term goal of this project is to develop a new microfluidic method for measuring the genome of viruses. Such a measurement will be valuable for assessing the quality of artificial viruses made for gene therapy. UROP role: Preference will be given to UROP Candidates aiming for a long-term internship (1+ year), with the goal of pursuing research in graduate school. Student will work closely with a postdoctoral researcher. The UROP milestones as part of this project consist of i) developing a simulation tool to investigate measured signal of viruses (6 months) ii) conduct experiments and connect results with simulations (12-months).


Knowledge of MATLAB programming and basic fluid mechanics. For later part (after 6 months) some hands-on experience is welcome.