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Disrupting activities of “undruggable” proteins




BI: Broad Institute

Faculty Supervisor:

Eric Lander

Faculty email:


Apply by:



Amit Choudhary: achoud@broadinstitute.org

Project Description

Many proteins have earned the moniker of “undruggable” as efforts to control their activities with small molecules (i.e. pharmacologic control) have failed despite their evident role in several diseases. You will join the Choudhary Lab to help develop a new class of small molecules that can potentially disrupt the activities of these “undruggable” proteins. You will work closely with a small team of postdoctoral fellows in chemistry and biology and have the opportunity to learn fundamental techniques and principles employed in organic chemistry, molecular and cell biology.


Some experience in organic chemistry, or cell and molecular biology desired, but not required. Spring term.