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Automated Nanomole-Scale Platform for Rapid Screening and Optimization of Electroorganic Synthesis


Term:

Spring

Department:

10: Chemical Engineering

Faculty Supervisor:

Klavs F. Jensen

Faculty email:

kfjensen@mit.edu

Apply by:

Contact:

yimingmo@mit.edu

Project Description

Electroorganic synthesis has recently emerged as a powerful tool for synthetic chemists to access unprecedented transformations under mild, and environmentally friendly conditions. However, the vast parameter space and prolonged reaction time of electroorganic synthesis create challenges to discover, optimize, and understand newly developed electrochemistry. In this project, we are aiming at developing a fully automated droplet-based screening platform to enable rapid examination of the electrochemical reactions with nanomole amount of reagents, which can potentially facilitate the mechanistic understanding of the electrochemical systems. This platform is expected to achieve 10-fold increase in screening throughput compared to the traditional batch screening approach. Electroanalysis based on cyclic voltammetry and electrochemical radical cross-coupling reactions will be demonstrated on this system. During this project, UROP students will have the opportunity to learn automated microfluidic systems, including software and hardware. In addition, students can also get familiar with some fundamentals of electrochemistry and organic chemistry Contact: Yiming Mo: yimingmo@mit.edu

Pre-requisites

Students with some programming and organic chemistry knowledge are welcome to apply for this project.